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Therapy Name GI-101
Synonyms
Therapy Description

GI-101 is a bispecific protein comprising the extracellular domain of CD80, which binds to and inhibits CTLA4, and an IL-2 variant that binds to IL2RB, which potentially leads to increased antitumor immune response and inhibition of tumor growth (Cancer Res 2020;80(16 Suppl):Abstract nr 6529).

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Drug Name Trade Name Synonyms Drug Classes Drug Description
GI-101 GI 101|GI101 CTLA4 Inhibitor 4 GI-101 is a bispecific protein comprising the extracellular domain of CD80, which binds to and inhibits CTLA4, and an IL-2 variant that binds to IL2RB, which potentially leads to increased antitumor immune response and inhibition of tumor growth (Cancer Res 2020;80(16 Suppl):Abstract nr 6529).

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

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  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
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  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries
NCT04977453 Phase Ib/II GI-101 GI-101 + Pembrolizumab GI-101 + Lenvatinib GI-101 as a Single Agent or in Combination With Pembrolizumab, Lenvatinib or Local Radiotherapy in Advanced Solid Tumors Recruiting USA 1


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