Therapy Detail
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| Therapy Name | Pegfilgrastim + Tivantinib + Topotecan |
| Synonyms | |
| Therapy Description | |
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| Drug Name | Trade Name | Synonyms | Drug Classes | Drug Description |
|---|---|---|---|---|
| Pegfilgrastim | Neulasta | GCSF-SD01 | Neulasta (Pegfilgrastim) is a pegylated version of filgrastim, a recombinant human granulocyte colony-stimulating factor (G-CSF), which enhances proliferation, differentiation, and activity of neutrophils (NCI Drug Dictionary). | |
| Tivantinib | ARQ197|ARQ 197|ARQ-197 | MET Inhibitor 59 | Tivantinib (ARQ197) inhibits MET and may have antimitotic activity, potentially resulting in decreased tumor cell proliferation and reduced tumor growth (PMID: 29924867, PMID: 28246274). | |
| Topotecan | Hycamtin | Topotecan Hcl | Topotecan binds to topoisomerase I and stablizes complexes with DNA, resulting in decreased repair of DNA single-strand breaks, and potentially leading to cell death (NCI Drug Dictionary). |
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| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|
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- Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")
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| Clinical Trial | Phase | Therapies | Title | Recruitment Status | Covered Countries | Other Countries |
|---|---|---|---|---|---|---|
| NCT01654965 | Phase I | Pegfilgrastim + Tivantinib + Topotecan | Tivantinib and Topotecan Hydrochloride in Treating Patients With Advanced or Metastatic Solid Tumors | Completed | USA | 0 |
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