Therapy Detail
Contact
Missing content? – Request curation!
Request curation for specific Genes, Variants, or PubMed publications.
Have questions, comments, or suggestions? - Let us know!
Email us at : ckbsupport@genomenon.com
| Therapy Name | Azeliragon |
| Synonyms | |
| Therapy Description |
Azeliragon inhibits the interaction between receptor for advanced glycation end products (RAGE) and its ligands, potentially resulting in decreased tumor cell viability (PMID: 34763082). |
Filtering
- Case insensitive filtering will display rows if any text in any cell matches the filter term
- Use simple literal full or partial string matches
- Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
- Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
- Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")
Sorting
- Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
- Click on any column header arrows to sort by that column
- Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.
| Drug Name | Trade Name | Synonyms | Drug Classes | Drug Description |
|---|---|---|---|---|
| Azeliragon | PF-04494700|TTP488 | Azeliragon inhibits the interaction between receptor for advanced glycation end products (RAGE) and its ligands, potentially resulting in decreased tumor cell viability (PMID: 34763082). |
Filtering
- Case insensitive filtering will display rows if any text in any cell matches the filter term
- Use simple literal full or partial string matches
- Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
- Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
- Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")
Sorting
- Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
- Click on any column header arrows to sort by that column
- Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.
| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|
Filtering
- Case insensitive filtering will display rows if any text in any cell matches the filter term
- Use simple literal full or partial string matches
- Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
- Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
- Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")
Sorting
- Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
- Click on any column header arrows to sort by that column
- Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.
| Clinical Trial | Phase | Therapies | Title | Recruitment Status | Covered Countries | Other Countries |
|---|---|---|---|---|---|---|
| NCT05789589 | Phase Ib/II | Azeliragon + Methylprednisolone Azeliragon Azeliragon + Dexamethasone | Effect of Azeliragon Combined With Stereotactic Radiation Therapy in Patients With Brain Metastases (ADORATION) | Recruiting | USA | 0 |
| NCT05766748 | Phase Ib/II | Azeliragon | Study of Effect of Azeliragon in Patients Refractory to First-Line Metastatic Pancreatic Cancer | Recruiting | USA | 0 |
| NCT05986851 | Phase II | Azeliragon | Azeliragon in MGMT Unmethylated Glioblastoma | Active, not recruiting | USA | 0 |
| NCT05635734 | Phase Ib/II | Azeliragon | Azeliragon and Chemoradiotherapy in Newly Diagnosed Glioblastoma | Active, not recruiting | ESP | 0 |
| NCT06724926 | Phase I | Azeliragon | Concurrent Azeliragon With Craniospinal Irradiation | Recruiting | USA | 0 |
CKB BOOST