Therapy Detail
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| Therapy Name | MK-4464 |
| Synonyms | |
| Therapy Description |
MK-4464 is an NK-cell engager targeting CEACAM5, which potentially induces killing of tumor cells expressing CEACAM5, resulting in inhibition of tumor growth (Cancer Res (2025) 85 (8_Supplement_1): 4364). |
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| Drug Name | Trade Name | Synonyms | Drug Classes | Drug Description |
|---|---|---|---|---|
| MK-4464 | MK4464|MK 4464 | CEACAM5 Antibody 12 | MK-4464 is an NK-cell engager targeting CEACAM5, which potentially induces killing of tumor cells expressing CEACAM5, resulting in inhibition of tumor growth (Cancer Res (2025) 85 (8_Supplement_1): 4364). |
Filtering
- Case insensitive filtering will display rows if any text in any cell matches the filter term
- Use simple literal full or partial string matches
- Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
- Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
- Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")
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| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|
Filtering
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- Use simple literal full or partial string matches
- Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
- Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
- Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")
Sorting
- Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
- Click on any column header arrows to sort by that column
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| Clinical Trial | Phase | Therapies | Title | Recruitment Status | Covered Countries | Other Countries |
|---|---|---|---|---|---|---|
| NCT05514444 | Phase I | MK-4464 MK-4464 + Pembrolizumab | Study of MK-4464 as Monotherapy and in Combination With Pembrolizumab in Participants With Advanced/Metastatic Solid Tumors (MK-4464-001) | Completed | USA | NLD | ISR | CAN | 0 |
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