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Therapy Name SC-CAR4BRAIN
Synonyms
Therapy Description

SC-CAR4BRAIN are autologous CD4+ and CD8+ T-lymphocytes engineered to express four chimeric antigen receptors (CARs) that target B7-H3, EGFR, ERBB2 (HER2), and interleukin-13 receptor alpha 2 (IL13Ra2), which potentially induce toxicity in B7-H3, EGFR, ERBB2 (HER2), and IL13Ra2-expressing tumor cells (NCI Drug Dictionary).

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Drug Name Trade Name Synonyms Drug Classes Drug Description
SC-CAR4BRAIN CD276 Immune Cell Therapy 10 IL13RA2 Immune Cell Therapy 7 SC-CAR4BRAIN are autologous CD4+ and CD8+ T-lymphocytes engineered to express four chimeric antigen receptors (CARs) that target B7-H3, EGFR, ERBB2 (HER2), and interleukin-13 receptor alpha 2 (IL13Ra2), which potentially induce toxicity in B7-H3, EGFR, ERBB2 (HER2), and IL13Ra2-expressing tumor cells (NCI Drug Dictionary).

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries
NCT05768880 Phase I SC-CAR4BRAIN Study of B7-H3, EGFR806, HER2, And IL13-Zetakine (Quad) CAR T Cell Locoregional Immunotherapy For Pediatric Diffuse Intrinsic Pontine Glioma, Diffuse Midline Glioma, And Recurrent Or Refractory Central Nervous System Tumors Active, not recruiting USA 0


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