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Therapy Name | SC-CAR4BRAIN |
Synonyms | |
Therapy Description |
SC-CAR4BRAIN are autologous CD4+ and CD8+ T-lymphocytes engineered to express four chimeric antigen receptors (CARs) that target B7-H3, EGFR, ERBB2 (HER2), and interleukin-13 receptor alpha 2 (IL13Ra2), which potentially induce toxicity in B7-H3, EGFR, ERBB2 (HER2), and IL13Ra2-expressing tumor cells (NCI Drug Dictionary). |