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Therapy Name BJ-005
Synonyms
Therapy Description

BJ-005 is a fusion protein comprising an anti-PD-L1 (CD274) antibody linked to the extracellular domain of Tgfbr2, which may decrease TGFbeta- and PD-L1-mediated immunosuppression, leading to increased antitumor immune response and reduced tumor cell proliferation (NCI Drug Dictionary).

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Drug Name Trade Name Synonyms Drug Classes Drug Description
BJ-005 BJ 005|BJ005 Immune Checkpoint Inhibitor 149 PD-L1/PD-1 antibody 121 BJ-005 is a fusion protein comprising an anti-PD-L1 (CD274) antibody linked to the extracellular domain of Tgfbr2, which may decrease TGFbeta- and PD-L1-mediated immunosuppression, leading to increased antitumor immune response and reduced tumor cell proliferation (NCI Drug Dictionary).

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries
NCT05115292 Phase I BJ-005 A First-in-Human, Phase 1 Dose-Escalation and Cohort Expansion Study to Evaluate the Safety, Tolerability, and Pharmacokinetics of BJ-005 in Patients With Advanced Solid Tumor or Lymphoma Active, not recruiting USA 0


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