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Therapy Name AL8326
Synonyms
Therapy Description

AL8326 is a tyrosine kinase inhibitor that inhibits Aurora B, Fgfr, and Vegfr, potentially leading to disrupted chromosome segregation, impaired cell division, decreased tumor cell proliferation, and antitumor activity (J Clin Oncol 41, 2023 (suppl 16; abstr 8585), NCI Drug Dictionary).

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Drug Name Trade Name Synonyms Drug Classes Drug Description
AL8326 AL-8326|AL 8326 Aurkb Inhibitors 22 FGFR Inhibitor (Pan) 26 VEGFR Inhibitor (Pan) 36 AL8326 is a tyrosine kinase inhibitor that inhibits Aurora B, Fgfr, and Vegfr, potentially leading to disrupted chromosome segregation, impaired cell division, decreased tumor cell proliferation, and antitumor activity (J Clin Oncol 41, 2023 (suppl 16; abstr 8585), NCI Drug Dictionary).

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries
NCT05363280 Phase II AL8326 Phase 2 Study for the Patient, Who Has Diagnosed With Small Cell Lung Cancer (SCLC) or Non Small Cell Lung Cancer (NSCLC) or Renal Cell Carcinoma (RCC) and Finished the First Line Stand Treatment , Need More Treatment Recruiting USA | ESP 0


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