Therapy Detail
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| Therapy Name | AFM28 |
| Synonyms | |
| Therapy Description |
AFM28 is a bispecific innate cell engager that redirects CD16A-positive NK cells towards CD123 (IL3RA)-positive tumor cells, potentially leading to antibody-dependent cellular cytotoxicity and decreased tumor growth (PMID: 40841539). |
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| Drug Name | Trade Name | Synonyms | Drug Classes | Drug Description |
|---|---|---|---|---|
| AFM28 | AFM-28|AFM 28 | CD123 (IL3RA) Antibody 14 | AFM28 is a bispecific innate cell engager that redirects CD16A-positive NK cells towards CD123 (IL3RA)-positive tumor cells, potentially leading to antibody-dependent cellular cytotoxicity and decreased tumor growth (PMID: 40841539). |
Filtering
- Case insensitive filtering will display rows if any text in any cell matches the filter term
- Use simple literal full or partial string matches
- Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
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- Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")
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| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|
Filtering
- Case insensitive filtering will display rows if any text in any cell matches the filter term
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- Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
- Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
- Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")
Sorting
- Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
- Click on any column header arrows to sort by that column
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| Clinical Trial | Phase | Therapies | Title | Recruitment Status | Covered Countries | Other Countries |
|---|---|---|---|---|---|---|
| NCT05817058 | Phase I | AFM28 | First-in-Human Dose Escalation Study of AFM28 in Patients With Relapsed/Refractory Acute Myeloid Leukemia | Terminated | FRA | ESP | 0 |
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