Therapy Detail
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| Therapy Name | AMT-116 |
| Synonyms | |
| Therapy Description |
AMT-116 is an antibody-drug conjugate (ADC) targeting CD44v9 conjugated to a topoisomerase I inhibitor, which potentially induces antitumor activity (J Clin Oncol 42, 2024 (suppl 16; abstr e15010)). |
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| Drug Name | Trade Name | Synonyms | Drug Classes | Drug Description |
|---|---|---|---|---|
| AMT-116 | AMT116|AMT 116 | AMT-116 is an antibody-drug conjugate (ADC) targeting CD44v9 conjugated to a topoisomerase I inhibitor, which potentially induces antitumor activity (J Clin Oncol 42, 2024 (suppl 16; abstr e15010)). |
Filtering
- Case insensitive filtering will display rows if any text in any cell matches the filter term
- Use simple literal full or partial string matches
- Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
- Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
- Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")
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- Click on any column header arrows to sort by that column
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| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|
Filtering
- Case insensitive filtering will display rows if any text in any cell matches the filter term
- Use simple literal full or partial string matches
- Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
- Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
- Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")
Sorting
- Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
- Click on any column header arrows to sort by that column
- Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.
| Clinical Trial | Phase | Therapies | Title | Recruitment Status | Covered Countries | Other Countries |
|---|---|---|---|---|---|---|
| NCT05725291 | Phase Ib/II | AMT-116 | AMT-116 in Patients With Selected Advanced Solid Tumors | Recruiting | USA | AUS | 1 |
| NCT07718737 | Phase II | Docetaxel Docetaxel + Ramucirumab AMT-116 | Global, Multicenter Study of AMT-116 Versus Investigator's Choice in Participants With Advanced or Metastatic Non-squamous EGFR-Wildtype Non-Small Cell Lung Cancer (NSCLC) With Progression on or After Platinum-Based Chemotherapy and Anti-PD-1/PD-L1 Immunotherapy | Not yet recruiting | AUS | 0 |
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