Therapy Detail
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| Therapy Name | Surufatinib + Toripalimab-tpzi |
| Synonyms | |
| Therapy Description | |
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| Drug Name | Trade Name | Synonyms | Drug Classes | Drug Description |
|---|---|---|---|---|
| Surufatinib | Sulfatinib|HMPL-012 | FGFR1 Inhibitor 28 VEGFR Inhibitor (Pan) 36 | Surufatinib (HMPL-012) is a dual VEGFR/FGFR1 inhibitor, which potentially results in reduced cell proliferation and migration, alteration of the tumor microenvironment, and inhibition of tumor angiogenesis and growth (PMID: 37361567). | |
| Toripalimab-tpzi | Loqtorz | Toripalimab|JS001|JS-001|TAB001 | Immune Checkpoint Inhibitor 149 PD-L1/PD-1 antibody 122 | Loqtorz (toripalimab-tpzi) is a monoclonal antibody that targets PD-1 (PDCD1) and inhibits binding of the PD-L1 (CD274) ligand, potentially resulting in enhanced anti-tumor immune response and decreased tumor growth (PMID: 28317872; PMID: 32277740, PMID: 32406293, PMID: 32321714). Loqtorz (toripalimab-tpzi) in combination with cisplatin and gemcitabine is FDA-approved for use in adult patients with metastatic or recurrent, locally advanced nasopharyngeal carcinoma (FDA.gov). |
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| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|---|---|---|---|---|---|---|
| CD274 positive | lung non-small cell carcinoma | predicted - sensitive | Surufatinib + Toripalimab-tpzi | Phase II | Actionable | In a Phase II trial, Surufatinib (HMPL-012) plus Loqtorz (toripalimab-tpzi) treatment resulted in an objective response rate of 57.1%, a disease control rate of 100%, a median duration of response of 8.31 months, a median progression-free survival of 9.63 months, a median overall survival (OS) that was not reached, and a 12-month OS rate of 64% in patients with CD274 (PD-L1)-positive (TPS>=1%) non-small cell lung cancer (Cancer Res (2023) 83 (8_Supplement): CT225; NCT04169672). | detail... |
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| Clinical Trial | Phase | Therapies | Title | Recruitment Status | Covered Countries | Other Countries |
|---|
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