Therapy Detail
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| Therapy Name | BMS-986449 |
| Synonyms | |
| Therapy Description |
BMS-986449 is a molecular glue degrader that induces CRBN-dependent proteasomal degradation of IKZF2 (Helios) and IKZF4 (Eos) in regulatory T-cells (Treg), which potentially induces Treg reprogramming and enhances antitumor immune response (Cancer Res (2025) 85 (8_Supplement_2): ND05, NCI Drug Dictionary). |
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| Drug Name | Trade Name | Synonyms | Drug Classes | Drug Description |
|---|---|---|---|---|
| BMS-986449 | BMS 986449|BMS986449 | BMS-986449 is a molecular glue degrader that induces CRBN-dependent proteasomal degradation of IKZF2 (Helios) and IKZF4 (Eos) in regulatory T-cells (Treg), which potentially induces Treg reprogramming and enhances antitumor immune response (Cancer Res (2025) 85 (8_Supplement_2): ND05, NCI Drug Dictionary). |
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| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|
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- Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")
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| Clinical Trial | Phase | Therapies | Title | Recruitment Status | Covered Countries | Other Countries |
|---|---|---|---|---|---|---|
| NCT05888831 | Phase Ib/II | BMS-986449 + Nivolumab BMS-986449 | A Study of BMS-986449 With and Without Nivolumab in Participants With Advanced Solid Tumors | Active, not recruiting | USA | NLD | ITA | FRA | ESP | BEL | 0 |
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