Therapy Detail
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| Therapy Name | B7-H3 CAR-T cells |
| Synonyms | |
| Therapy Description |
B7-H3 CAR-T cells are T-cells engineered to express a chimeric antigen receptor (CAR) targeting B7-H3 (CD276), which potentially inhibit growth of B7-H3-positive tumors (Cancer Res (2023) 83 (7_Supplement): 1197). |
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| Drug Name | Trade Name | Synonyms | Drug Classes | Drug Description |
|---|---|---|---|---|
| B7-H3 CAR-T cells | B7H3-CAR T|B7-H3CART | CD276 Immune Cell Therapy 10 | B7-H3 CAR-T cells are T-cells engineered to express a chimeric antigen receptor (CAR) targeting B7-H3 (CD276), which potentially inhibit growth of B7-H3-positive tumors (Cancer Res (2023) 83 (7_Supplement): 1197). |
Filtering
- Case insensitive filtering will display rows if any text in any cell matches the filter term
- Use simple literal full or partial string matches
- Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
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- Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")
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| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|
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- Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
- Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
- Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")
Sorting
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- Click on any column header arrows to sort by that column
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| Clinical Trial | Phase | Therapies | Title | Recruitment Status | Covered Countries | Other Countries |
|---|---|---|---|---|---|---|
| NCT07222735 | Phase I | Cyclophosphamide + Fludarabine B7-H3 CAR-T cells | Hypofractionated Radiation in Combination With B7-H3-CAR T Cells for Pediatric Patients With Relapsed/Refractory Sarcomas | Recruiting | USA | 0 |
| NCT05835687 | Phase I | B7-H3 CAR-T cells | Loc3CAR: Locoregional Delivery of B7-H3-CAR T Cells for Pediatric Patients With Primary CNS Tumors | Recruiting | USA | 0 |
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