Therapy Detail
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| Therapy Name | AMT-562 |
| Synonyms | |
| Therapy Description |
AMT-562 is an antibody drug conjugate (ADC) comprising an ERBB3 (HER3) antibody conjugated to exatecan, which potentially inhibits tumor growth (PMID: 37302522). |
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| Drug Name | Trade Name | Synonyms | Drug Classes | Drug Description |
|---|---|---|---|---|
| AMT-562 | AMT 562|AMT562 | HER3 (ERBB3) Antibody 30 | AMT-562 is an antibody drug conjugate (ADC) comprising an ERBB3 (HER3) antibody conjugated to exatecan, which potentially inhibits tumor growth (PMID: 37302522). |
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| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|---|---|---|---|---|---|---|
| BRAF V487_P492delinsA ERBB3 pos | pancreatic cancer | sensitive | AMT-562 | Preclinical - Cell line xenograft | Actionable | In a preclinical study, AMT-562 inhibited growth in a cell line xenograft model of ERBB3 (HER3)-positive pancreatic cancer harboring BRAF V487_P492delinsA (PMID: 37302522). | 37302522 |
| ERBB3 amp | rectum cancer | sensitive | AMT-562 | Preclinical - Pdx | Actionable | In a preclinical study, AMT-562 inhibited tumor growth in a patient-derived xenograft (PDX) model of ERBB3 (HER3)-amplified rectal cancer (PMID: 37302522). | 37302522 |
| ERBB3 positive | colon cancer | sensitive | AMT-562 | Preclinical - Cell line xenograft | Actionable | In a preclinical study, AMT-562 inhibited tumor growth in a cell line xenograft model of ERBB3 (HER3)-positive colon cancer with a complete response in 4 of 5 mice and inhibited growth in patient-derived organoids in culture (PMID: 37302522). | 37302522 |
| ERBB3 positive | lung non-small cell carcinoma | sensitive | AMT-562 | Preclinical - Cell line xenograft | Actionable | In a preclinical study, AMT-562 inhibited tumor growth in a cell line xenograft model of ERBB3 (HER3)-positive non-small cell lung cancer (PMID: 37302522). | 37302522 |
| BRAF V600E ERBB3 pos | colon cancer | sensitive | AMT-562 | Preclinical - Cell line xenograft | Actionable | In a preclinical study, AMT-562 inhibited tumor growth in a cell line xenograft model of ERBB3 (HER3)-positive colon cancer harboring BRAF V600E (PMID: 37302522): | 37302522 |
| ERBB3 positive | breast cancer | predicted - sensitive | AMT-562 | Preclinical - Cell line xenograft | Actionable | In a preclinical study, AMT-562 inhibited tumor growth in a cell line xenograft model of low ERBB3 (HER3)-expressing breast cancer (PMID: 37302522). | 37302522 |
| ERBB3 positive | esophagus adenocarcinoma | sensitive | AMT-562 | Preclinical - Pdx | Actionable | In a preclinical study, AMT-562 inhibited tumor growth in a patient-derived xenograft (PDX) model of ERBB3 (HER3)-positive esophageal adenocarcinoma (PMID: 37302522). | 37302522 |
| ERBB3 positive | esophagus squamous cell carcinoma | sensitive | AMT-562 | Preclinical - Pdx | Actionable | In a preclinical study, AMT-562 inhibited tumor growth in a patient-derived xenograft (PDX) model of ERBB3 (HER3)-positive esophageal squamous cell carcinoma (PMID: 37302522). | 37302522 |
| ERBB3 positive | gastroesophageal junction adenocarcinoma | sensitive | AMT-562 | Preclinical - Pdx | Actionable | In a preclinical study, AMT-562 inhibited tumor growth in a patient-derived xenograft (PDX) model of ERBB3 (HER3)-positive gastroesophageal junction adenocarcinoma (PMID: 37302522). | 37302522 |
| ERBB3 positive | stomach cancer | sensitive | AMT-562 | Preclinical - Cell line xenograft | Actionable | In a preclinical study, AMT-562 inhibited tumor growth in a cell line xenograft model of ERBB3 (HER3)-positive gastric cancer (PMID: 37302522). | 37302522 |
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| Clinical Trial | Phase | Therapies | Title | Recruitment Status | Covered Countries | Other Countries |
|---|---|---|---|---|---|---|
| NCT06199908 | Phase I | AMT-562 | AMT-562 in Patients With Selected Advanced Solid Tumors | Unknown status | AUS | 0 |
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