Therapy Detail
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| Therapy Name | YX-02-030 |
| Synonyms | |
| Therapy Description |
YX-02-030 is a proteolysis-targeted chimera (PROTAC) that binds to MDM2 and targets it for degradation, potentially leading to tumor cell death (PMID: 36734633). |
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| Drug Name | Trade Name | Synonyms | Drug Classes | Drug Description |
|---|---|---|---|---|
| YX-02-030 | YX-02030|YX 02030|YX 02 030 | MDM2 Inhibitor 23 | YX-02-030 is a proteolysis-targeted chimera (PROTAC) that binds to MDM2 and targets it for degradation, potentially leading to tumor cell death (PMID: 36734633). |
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| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|---|---|---|---|---|---|---|
| MDM2 pos TP53 del | triple-receptor negative breast cancer | sensitive | YX-02-030 | Preclinical - Cell line xenograft | Actionable | In a preclinical study, YX-02-030 decreased Mdm2 expression, increased apoptosis, and decreased survival, colony formation, and mammosphere formation in triple-negative breast cancer cell lines harboring TP53 deletion in culture, and decreased tumor growth and increased survival in a cell line xenograft model (PMID: 36734633). | 36734633 |
| MDM2 pos TP53 R248Q TP53 R267L TP53 R273H | triple-receptor negative breast cancer | sensitive | YX-02-030 | Preclinical - Patient cell culture | Actionable | In a preclinical study, YX-02-030 decreased Mdm2 expression and increased apoptosis in patient-derived triple-negative breast cancer explants harboring TP53 R248Q, R267L, and R273H in culture (PMID: 36734633). | 36734633 |
| MDM2 pos TP53 G266E | triple-receptor negative breast cancer | sensitive | YX-02-030 | Preclinical - Patient cell culture | Actionable | In a preclinical study, YX-02-030 decreased Mdm2 expression and increased apoptosis in patient-derived triple-negative breast cancer explants harboring TP53 G266E in culture (PMID: 36734633). | 36734633 |
| MDM2 pos TP53 D281Y | triple-receptor negative breast cancer | sensitive | YX-02-030 | Preclinical - Patient cell culture | Actionable | In a preclinical study, YX-02-030 decreased Mdm2 expression and increased apoptosis in patient-derived triple-negative breast cancer explants harboring TP53 D281Y in culture and increased apoptosis and decreased survival in 3D mammosphere cultures (PMID: 36734633). | 36734633 |
| MDM2 pos TP53 R175H | triple-receptor negative breast cancer | sensitive | YX-02-030 | Preclinical - Cell culture | Actionable | In a preclinical study, YX-02-030 decreased Mdm2 expression and survival in triple-negative breast cancer cells harboring TP53 R175H in culture (PMID: 36734633). | 36734633 |
| MDM2 pos TP53 R248Q | triple-receptor negative breast cancer | sensitive | YX-02-030 | Preclinical - Patient cell culture | Actionable | In a preclinical study, YX-02-030 decreased survival in a triple-negative breast cancer (TNBC) cell line harboring TP53 R248Q in culture, decreased Mdm2 expression and increased apoptosis in patient-derived TNBC explants in culture, and increased apoptosis and decreased survival in 3D mammosphere cultures (PMID: 36734633). | 36734633 |
| MDM2 pos TP53 R280K | triple-receptor negative breast cancer | sensitive | YX-02-030 | Preclinical - Cell line xenograft | Actionable | In a preclinical study, YX-02-030 decreased Mdm2 expression, increased apoptosis, and decreased survival, colony formation, and mammosphere formation in a triple-negative breast cancer cell line harboring TP53 R280K in culture and decreased tumor growth and increased survival in a cell line xenograft model (PMID: 36734633). | 36734633 |
| MDM2 pos TP53 wild-type | triple-receptor negative breast cancer | sensitive | YX-02-030 | Preclinical - Cell culture | Actionable | In a preclinical study, YX-02-030 decreased Mdm2 expression, increased apoptosis, decreased survival, and decreased mammosphere formation in TP53 wild-type triple-negative breast cancer cell lines in culture (PMID: 36734633). | 36734633 |
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| Clinical Trial | Phase | Therapies | Title | Recruitment Status | Covered Countries | Other Countries |
|---|
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