Therapy Detail
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| Therapy Name | HER-2/neu intracellular domain protein + Polysaccharide-K + Trastuzumab |
| Synonyms | |
| Therapy Description | |
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| Drug Name | Trade Name | Synonyms | Drug Classes | Drug Description |
|---|---|---|---|---|
| HER-2/neu intracellular domain protein | HER-2 ICD Peptide|HER-2-neu ICD Protein | HER-2/neu intracellular domain protein is the cytoplasmic domain of the Her-2 protein, which may enhance the T-cell response against Her-2 expressing tumor cells when administered with trastuzumab (NCI Drug Dictionary). | ||
| Polysaccharide-K | Krestin|PSK | Krestin (polysaccharide-K) is a mushroom-derived immunomodulator that has been demonstrated to reduce immunosuppression and enhance anti-tumor immunity. Krestin has also been shown to reduce proliferation and induce apoptosis in tumor cells (PMID: 22139128). | ||
| Trastuzumab | Herceptin | Anti HER2 | HER2 (ERBB2) Antibody 77 | Herceptin (trastuzumab) is a monoclonal antibody, which binds ERBB2 (HER2) to induce tumor cellular cytotoxicity (PMID: 17611206). Herceptin (trastuzumab) is FDA approved for HER2-overexpressing (or amplification) breast cancer, gastric adenocarcinoma, and gastroesophageal junction adenocarcinoma (FDA.gov). |
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| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|
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| Clinical Trial | Phase | Therapies | Title | Recruitment Status | Covered Countries | Other Countries |
|---|
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