Therapy Detail
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| Therapy Name | Cyclophosphamide + Dexamethasone + Mesna + Vincristine Sulfate |
| Synonyms | |
| Therapy Description | |
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| Drug Name | Trade Name | Synonyms | Drug Classes | Drug Description |
|---|---|---|---|---|
| Cyclophosphamide | Cytoxan | CPM | Chemotherapy - Alkylating 18 | Cytoxan (cyclophosphamide) is an alkylating agent, which inhibits DNA replication (NCI Drug Dictionary). Cytoxan (cyclophosphamide) is FDA approved in multiple hematological malignancies, breast cancer, neuroblastoma, ovarian cancer, and retinoblastoma (NCI Drug Dictionary). |
| Dexamethasone | Adexone | Desametasone | ||
| Mesna | Mesnex | D-7093|UCB 398|MSA|mercaptoethane sulfonate|Mesnum | ||
| Vincristine Sulfate | Oncovin | 22-Oxovincaleukoblastine|vincristine | Oncovin (vincristine) binds microtubules and prevents mitotic spindle formation, resulting in cell-cycle arrest (NCI Drug Dictionary). |
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| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|
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| Clinical Trial | Phase | Therapies | Title | Recruitment Status | Covered Countries | Other Countries |
|---|---|---|---|---|---|---|
| NCT05303792 | Phase II | Cytarabine + Methotrexate + Methylprednisolone Cyclophosphamide + Dexamethasone + Mesna + Vincristine Sulfate Cytarabine + Inotuzumab ozogamicin + Methotrexate + Methylprednisolone Cyclophosphamide + Dexamethasone + Inotuzumab ozogamicin + Mesna + Vincristine Sulfate Cyclophosphamide + Dexamethasone + Mesna + Rituximab + Vincristine Sulfate Cyclophosphamide + Dexamethasone + Inotuzumab ozogamicin + Mesna + Rituximab + Vincristine Sulfate Cytarabine + Methotrexate + Methylprednisolone + Rituximab Mercaptopurine + Methotrexate + Prednisone + Vincristine Sulfate Cytarabine + Inotuzumab ozogamicin + Methotrexate + Methylprednisolone + Rituximab | Comparing Inotuzumab Combined With Low Intensity Chemotherapy Plus Blinatumomab to Usual Chemotherapy Plus Blinatumomab in Older Adults With CD22+ B-cell Acute Lymphoblastic Leukemia | Active, not recruiting | USA | 1 |
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