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Therapy Detail

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Therapy Name Taladegib
Synonyms
Therapy Description

Taladegib (LY-2940680) inhibits Smo, thereby inhibiting Hedgehog signaling and subsequent cell proliferation (Cancer Res 2011;71(8 Suppl):Abstract nr 2819, PMID: 29483143, PMID: 29453627).

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Drug Name Trade Name Synonyms Drug Classes Drug Description
Taladegib LY2940680|LY-2940680|ENV-101 SMO Inhibitor 16 Taladegib (LY-2940680) inhibits Smo, thereby inhibiting Hedgehog signaling and subsequent cell proliferation (Cancer Res 2011;71(8 Suppl):Abstract nr 2819, PMID: 29483143, PMID: 29453627).

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References

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Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries
NCT02530437 Phase Ib/II Taladegib Carboplatin + Paclitaxel A Phase 1B/2 Study of LY2940680 in Combination With Weekly Paclitaxel, Carboplatin, and Radiation in Localized Adenocarcinoma of the Esophagus or Gastroesophageal Junction Terminated USA 0
NCT01722292 Phase Ib/II Taladegib Carboplatin + Etoposide A Study of LY2940680 in Small Cell Lung Cancer Terminated USA | GBR 0
NCT05199584 Phase II Taladegib A Study Evaluating the Safety and Efficacy of ENV-101 (Taladegib) in Patients With Advanced Solid Tumors Harboring PTCH1 Loss of Function Mutations Active, not recruiting USA 0


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