Therapy Detail
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| Therapy Name | FT522 |
| Synonyms | |
| Therapy Description |
FT522 comprises allogeneic iPSC-derived NK cells engineered to express a chimeric antigen receptor (CAR) targeting CD19, a CD16 Fc receptor, a recombinant fusion of IL-15 and IL-15RF, and an alloimmune defense receptor (ADR) targeting TNFRSF9 (4-1BB), and to eliminate expression of CD38, which potentially enhances antibody-dependent cellular cytotoxicity (ADCC) and antitumor immune response (Blood (2024) 144 (Supplement 1): 6543, NCI Drug Dictionary). |
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| Drug Name | Trade Name | Synonyms | Drug Classes | Drug Description |
|---|---|---|---|---|
| FT522 | FT-522|FT 522 | CD19 Immune Cell Therapy 64 | FT522 comprises allogeneic iPSC-derived NK cells engineered to express a chimeric antigen receptor (CAR) targeting CD19, a CD16 Fc receptor, a recombinant fusion of IL-15 and IL-15RF, and an alloimmune defense receptor (ADR) targeting TNFRSF9 (4-1BB), and to eliminate expression of CD38, which potentially enhances antibody-dependent cellular cytotoxicity (ADCC) and antitumor immune response (Blood (2024) 144 (Supplement 1): 6543, NCI Drug Dictionary). |
Filtering
- Case insensitive filtering will display rows if any text in any cell matches the filter term
- Use simple literal full or partial string matches
- Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
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- Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")
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| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|
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- Case insensitive filtering will display rows if any text in any cell matches the filter term
- Use simple literal full or partial string matches
- Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
- Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
- Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")
Sorting
- Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
- Click on any column header arrows to sort by that column
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| Clinical Trial | Phase | Therapies | Title | Recruitment Status | Covered Countries | Other Countries |
|---|
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