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Therapy Name BNT314
Synonyms
Therapy Description

BNT314 (GEN1059) is a bispecific antibody targeting TNFRSF9 (4-1BB) and EpCAM, which potentially induces antitumor immune activity (Ann Oncol (2023) 34 (suppl_2): S619-S650).

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Drug Name Trade Name Synonyms Drug Classes Drug Description
BNT314 BNT 314|BNT-314|GEN1059|GEN 1059|GEN-1059 TNFRSF9 Antibody 32 BNT314 (GEN1059) is a bispecific antibody targeting TNFRSF9 (4-1BB) and EpCAM, which potentially induces antitumor immune activity (Ann Oncol (2023) 34 (suppl_2): S619-S650).

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries
NCT06150183 Phase Ib/II BNT314 + Pembrolizumab BNT314 Safety and Preliminary Efficacy of BNT314 With or Without an Immune Checkpoint Inhibitor in Cancer Patients With Malignant Solid Tumors Recruiting USA | GBR | ESP | DNK | BEL 1


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