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Therapy Name GD2-CART01
Synonyms
Therapy Description

GD2-CART01 comprises T-lymphocytes engineered to express a chimeric antigen receptor (CAR) that targets GD2 and contains CD28 and TNFRSF9 (4-1BB) costimulatory domains, along with inducible Caspase-9, which potentially induces cytotoxicity against GD2-expressing tumor cells and inhibits tumor growth (PMID: 29872565)

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Drug Name Trade Name Synonyms Drug Classes Drug Description
GD2-CART01 iC9-GD2-CAR T-cells GD2-CART01 comprises T-lymphocytes engineered to express a chimeric antigen receptor (CAR) that targets GD2 and contains CD28 and TNFRSF9 (4-1BB) costimulatory domains, along with inducible Caspase-9, which potentially induces cytotoxicity against GD2-expressing tumor cells and inhibits tumor growth (PMID: 29872565)

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries
NCT03373097 Phase Ib/II GD2-CART01 Anti-GD2 CAR T Cells in Pediatric Patients Affected by High Risk and/or Relapsed/Refractory Neuroblastoma or Other GD2-positive Solid Tumors Active, not recruiting ITA 0
NCT05298995 Phase I GD2-CART01 GD2-CAR T Cells for Pediatric Brain Tumours Recruiting ITA 0


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