Therapy Detail
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| Therapy Name | HC-7366 + Venetoclax |
| Synonyms | |
| Therapy Description | |
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| Drug Name | Trade Name | Synonyms | Drug Classes | Drug Description |
|---|---|---|---|---|
| HC-7366 | HC 7366|HC7366|HC 7366-K|HC7366-K|HC-7366-K | HC-7366 is a modulator of GCN2 kinase, which potentially inhibits tumors growth (J Clin Oncol 40, no. 16_suppl (June 01, 2022) TPS3179). | ||
| Venetoclax | Venclexta | ABT-199|RG7601|GDC-0199|ABT119|Venclyxto | BCL2 inhibitor 27 | Venclexta (venetoclax) is a BH3-mimetic that binds to and inhibits BCL2, resulting in increased tumor cell apoptosis (PMID: 26589495, PMID: 25048785). Venclexta (venetoclax) is FDA approved for use in patients with chronic lymphocytic leukemia (CLL) or small lymphocytic lymphoma (SLL), and in combination with chemotherapy in patients 75 years old or older with newly-diagnosed acute myeloid leukemia (FDA.gov). |
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| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|---|---|---|---|---|---|---|
| FLT3 exon 14 ins | acute myeloid leukemia | predicted - sensitive | HC-7366 + Venetoclax | Preclinical - Cell line xenograft | Actionable | In a preclinical study, treatment with the combination of HC-7366 and Venclexta (venetoclax) resulted in tumor regression in a cell line xenograft model of acute myeloid leukemia harboring a FLT3 ITD mutation (Blood (2023) 142 (Supplement 1): 2943). | detail... |
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| Clinical Trial | Phase | Therapies | Title | Recruitment Status | Covered Countries | Other Countries |
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