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Therapy Detail
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| Therapy Name | AZD9829 |
| Synonyms | |
| Therapy Description |
AZD9829 is an antibody-drug conjugate (ADC) comprising an IL3RA (CD123)-targeted antibody linked to the TOP1 inhibitor AZ14170132, which potentially induces DNA damage and apoptosis in IL3RA (CD123)-expressing cancer cells and inhibits tumor growth (Blood (2023) 142 (Supplement 1): 5957). |
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| Drug Name | Trade Name | Synonyms | Drug Classes | Drug Description |
|---|---|---|---|---|
| AZD9829 | AZD 9829|AZD-9829 | AZD9829 is an antibody-drug conjugate (ADC) comprising an IL3RA (CD123)-targeted antibody linked to the TOP1 inhibitor AZ14170132, which potentially induces DNA damage and apoptosis in IL3RA (CD123)-expressing cancer cells and inhibits tumor growth (Blood (2023) 142 (Supplement 1): 5957). |
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| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|
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| Clinical Trial | Phase | Therapies | Title | Recruitment Status | Covered Countries | Other Countries |
|---|---|---|---|---|---|---|
| NCT06179511 | Phase Ib/II | AZD9829 | Study of AZD9829 in CD123+ Hematological Malignancies | Recruiting | USA | ITA | GBR | ESP | DEU | AUS | 4 |
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