Therapy Detail
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| Therapy Name | Obecabtagene autoleucel |
| Synonyms | |
| Therapy Description |
Aucatzyl (obecabtagene autoleucel) comprises autologous T-lymphocytes engineered to express a chimeric antigen receptor (CAR) targeting CD19, which potentially decreases tumor growth (J Clin Oncol 41, no. 16_suppl (June 01, 2023) 7000). Aucatzyl (obecabtagene autoleucel) is FDA-approved for use in adult patients with relapsed or refractory B-cell precursor acute lymphoblastic leukemia (FDA.gov). |
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| Drug Name | Trade Name | Synonyms | Drug Classes | Drug Description |
|---|---|---|---|---|
| Obecabtagene autoleucel | Aucatzyl | Obe-cel|AUTO1|AUTO-1|AUTO 1 | CD19 Immune Cell Therapy 72 | Aucatzyl (obecabtagene autoleucel) comprises autologous T-lymphocytes engineered to express a chimeric antigen receptor (CAR) targeting CD19, which potentially decreases tumor growth (J Clin Oncol 41, no. 16_suppl (June 01, 2023) 7000). Aucatzyl (obecabtagene autoleucel) is FDA-approved for use in adult patients with relapsed or refractory B-cell precursor acute lymphoblastic leukemia (FDA.gov). |
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| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|
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| Clinical Trial | Phase | Therapies | Title | Recruitment Status | Covered Countries | Other Countries |
|---|---|---|---|---|---|---|
| NCT07053059 | Phase II | Obecabtagene autoleucel | Phase 2 Study Assessing the Clinical Activity and Safety of Obecabtagene Autoleucel as a Consolidation in Patients With Newly Diagnosed High-risk B-cell Acute Lymphocytic Leukemia (ALL) | Recruiting | USA | 0 |
| NCT06173518 | Phase I | Obecabtagene autoleucel | A Study of CD19 Targeted CAR T Cell Therapy in Pediatric Patients With Relapsed or Refractory B Cell Acute Lymphoblastic Leukemia (B ALL) and Aggressive Mature B-cell Non-Hodgkin Lymphoma (B NHL) | Recruiting | USA | GBR | ESP | 0 |
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