Therapy Detail
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| Therapy Name | Nab-paclitaxel + Toripalimab-tpzi |
| Synonyms | |
| Therapy Description | |
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| Drug Name | Trade Name | Synonyms | Drug Classes | Drug Description |
|---|---|---|---|---|
| Nab-paclitaxel | Abraxane | ABI-007|Paclitaxel Protein-bound | Chemotherapy - Taxane 3 | Abraxane (nab-paclitaxel) is an albumin-stablized version of paclitaxel, which binds microtubules and prevents depolymerization, resulting in decreased cell motility and division (NCI Drug Dictionary). |
| Toripalimab-tpzi | Loqtorz | Toripalimab|JS001|JS-001|TAB001 | Immune Checkpoint Inhibitor 149 PD-L1/PD-1 antibody 122 | Loqtorz (toripalimab-tpzi) is a monoclonal antibody that targets PD-1 (PDCD1) and inhibits binding of the PD-L1 (CD274) ligand, potentially resulting in enhanced anti-tumor immune response and decreased tumor growth (PMID: 28317872; PMID: 32277740, PMID: 32406293, PMID: 32321714). Loqtorz (toripalimab-tpzi) in combination with cisplatin and gemcitabine is FDA-approved for use in adult patients with metastatic or recurrent, locally advanced nasopharyngeal carcinoma (FDA.gov). |
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| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|---|---|---|---|---|---|---|
| CD274 positive | triple-receptor negative breast cancer | predicted - sensitive | Nab-paclitaxel + Toripalimab-tpzi | Phase III | Actionable | In a Phase III trial (TORCHLIGHT), treatment with Loqtorz (toripalimab-tpzi) plus Abraxane (nab-paclitaxel) demonstrated safety and led to an improved median progression-free survival (mPFS) compared to nab-paclitaxel plus placebo in CD274 (PD-L1)-positive (CPS >/= 1) triple-negative breast cancer patients, with a mPFS of 8.4 vs 5.6 mo (HR=0.65, p=0.0102) and in the intention to treat population, a mPFS of 8.4 vs 6.9 mo (PMID: 38191615; NCT03777579, NCT04085276). | 38191615 |
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| Clinical Trial | Phase | Therapies | Title | Recruitment Status | Covered Countries | Other Countries |
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