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Therapy Name AFNT-211
Synonyms
Therapy Description

AFNT-211 comprises autologous T-cells expressing a T-cell receptor targeting KRAS G12V in the context of HLA-A*11:010 and modified to enhance cell persistence, which potentially induces antitumor immune activity and cytotoxicity in KRAS G12V-expressing tumor cells (J Clin Oncol, 41, no. 16_suppl (2023) 2543).

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Drug Name Trade Name Synonyms Drug Classes Drug Description
AFNT-211 AFNT211|AFNT 211 AFNT-211 comprises autologous T-cells expressing a T-cell receptor targeting KRAS G12V in the context of HLA-A*11:010 and modified to enhance cell persistence, which potentially induces antitumor immune activity and cytotoxicity in KRAS G12V-expressing tumor cells (J Clin Oncol, 41, no. 16_suppl (2023) 2543).

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

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  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries
NCT06105021 Phase Ib/II AFNT-211 Phase I Study of Autologous CD8+ and CD4+ Engineered T Cell Receptor T Cells in Subjects With Advanced or Metastatic Solid Tumor Recruiting USA 0


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