Therapy Detail
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| Therapy Name | AFNT-211 |
| Synonyms | |
| Therapy Description |
AFNT-211 comprises autologous T-cells expressing a T-cell receptor targeting KRAS G12V in the context of HLA-A*11:010 and modified to enhance cell persistence, which potentially induces antitumor immune activity and cytotoxicity in KRAS G12V-expressing tumor cells (J Clin Oncol, 41, no. 16_suppl (2023) 2543). |
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| Drug Name | Trade Name | Synonyms | Drug Classes | Drug Description |
|---|---|---|---|---|
| AFNT-211 | AFNT211|AFNT 211 | AFNT-211 comprises autologous T-cells expressing a T-cell receptor targeting KRAS G12V in the context of HLA-A*11:010 and modified to enhance cell persistence, which potentially induces antitumor immune activity and cytotoxicity in KRAS G12V-expressing tumor cells (J Clin Oncol, 41, no. 16_suppl (2023) 2543). |
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| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|
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- Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")
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| Clinical Trial | Phase | Therapies | Title | Recruitment Status | Covered Countries | Other Countries |
|---|---|---|---|---|---|---|
| NCT06105021 | Phase Ib/II | AFNT-211 | Phase I Study of Autologous CD8+ and CD4+ Engineered T Cell Receptor T Cells in Subjects With Advanced or Metastatic Solid Tumor | Active, not recruiting | USA | 0 |
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