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Therapy Name ABBV-303
Synonyms
Therapy Description

ABBV-303 is a tri-specific natural killer (NK) cell engager that binds to NKG2D and CD16a expressed on NK cells and MET expressed on tumor cells and directs NK cells and CD8+ T-lymphocytes towards MET-expressing tumor cells, potentially resulting in increased tumor cell killing (Cancer Res (2024) 84 (7_Supplement): ND01, NCI Drug Dictionary).

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Drug Name Trade Name Synonyms Drug Classes Drug Description
ABBV-303 ABBV 303|ABBV303 MET Antibody 37 ABBV-303 is a tri-specific natural killer (NK) cell engager that binds to NKG2D and CD16a expressed on NK cells and MET expressed on tumor cells and directs NK cells and CD8+ T-lymphocytes towards MET-expressing tumor cells, potentially resulting in increased tumor cell killing (Cancer Res (2024) 84 (7_Supplement): ND01, NCI Drug Dictionary).

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries
NCT06158958 Phase I ABBV-303 + Budigalimab ABBV-303 A Study of Adverse Events, How Intravenously (IV) Infused ABBV-303 Moves Through the Body, and Change in Disease State, as Monotherapy and in Combination With IV Infused Budigalimab (ABBV-181), in Adult Participants With Advanced Solid Tumors Terminated USA | ISR 1


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