Therapy Detail
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| Therapy Name | ABBV-303 |
| Synonyms | |
| Therapy Description |
ABBV-303 is a tri-specific natural killer (NK) cell engager that binds to NKG2D and CD16a expressed on NK cells and c-MET expressed on tumor cells and redirects NK cells and CD8+ T-lymphocytes towards MET-expressing tumor cells, potentially resulting in increased tumor cell killing (Cancer Res (2024) 84 (7_Supplement): ND01, NCI Drug Dictionary). |
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| Drug Name | Trade Name | Synonyms | Drug Classes | Drug Description |
|---|---|---|---|---|
| ABBV-303 | ABBV 303|ABBV303 | MET Immune Cell Therapy 2 | ABBV-303 is a tri-specific natural killer (NK) cell engager that binds to NKG2D and CD16a expressed on NK cells and c-MET expressed on tumor cells and redirects NK cells and CD8+ T-lymphocytes towards MET-expressing tumor cells, potentially resulting in increased tumor cell killing (Cancer Res (2024) 84 (7_Supplement): ND01, NCI Drug Dictionary). |
Filtering
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- Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")
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| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|
Filtering
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- Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
- Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
- Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")
Sorting
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- Click on any column header arrows to sort by that column
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| Clinical Trial | Phase | Therapies | Title | Recruitment Status | Covered Countries | Other Countries |
|---|---|---|---|---|---|---|
| NCT06158958 | Phase I | ABBV-303 + Budigalimab ABBV-303 | A Study of Adverse Events, How Intravenously (IV) Infused ABBV-303 Moves Through the Body, and Change in Disease State, as Monotherapy and in Combination With IV Infused Budigalimab (ABBV-181), in Adult Participants With Advanced Solid Tumors | Recruiting | USA | ISR | 1 |
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