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Therapy Name Belantamab + Belantamab mafodotin-blmf + Dexamethasone + Lenalidomide
Synonyms
Therapy Description

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Drug Name Trade Name Synonyms Drug Classes Drug Description
Belantamab GSK2857914|GSK-2857914|GSK 2857914 TNFRSF17 Antibody 22 Belantamab is a monoclonal antibody targeting TNFRSF17 (BCMA), which potentially decreases tumor growth (PMID: 34253590).
Belantamab mafodotin-blmf Blenrep anti-BCMA ADC GSK2857916|J6M0-mcMMAF|GSK2857916 TNFRSF17 Antibody 22 Blenrep (belantamab mafodotin-blmf) is an antibody-drug conjugate comprising an antibody targeting BCMA linked to monomethyl auristatin F, which delivers the anti-microtubule agent to BCMA-expressing tumor cells, potentially resulting in increased tumor cell death and decreased tumor growth (PMID: 30442502, PMID: 24569262). Blenrep (belantamab mafodotin-blmf) in combination with Velcade (bortezomib), and Dexamethasone is FDA-approved for adult patients with relapsed or refractory multiple myeloma who have received at least two prior lines of therapy (FDA.gov).
Dexamethasone Adexone Desametasone
Lenalidomide Revlimid IMiD-1 Revlimid (lenalidomide) is a thalidomide analog which regulates cytokine production and stimulates T cells and NK cells activity (PMID: 24328678). Revlimid (lenalidomide) is FDA approved for use in multiple myeloma, relapsed or refractory Mantle cell lymphoma, and in combination with a rituximab product in follicular lymphoma and marginal zone lymphoma (FDA.gov).

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References

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Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries
NCT05714839 Phase I Belantamab Belantamab + Belantamab mafodotin-blmf + Dexamethasone + Lenalidomide Belantamab mafodotin-blmf A Study to Investigate the Safety and Efficacy of Belantamab for the Treatment of Multiple Myeloma When Used as Monotherapy and in Combination Treatments (DREAMM-20) Recruiting USA | POL | GBR | BRA | AUS | ARG 3


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