Therapy Detail
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| Therapy Name | Temozolomide + TGF-beta-imprinted NK cells |
| Synonyms | |
| Therapy Description | |
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| Drug Name | Trade Name | Synonyms | Drug Classes | Drug Description |
|---|---|---|---|---|
| TGF-beta-imprinted NK cells | TGF-beta-imprinted NK cells are natural killer cells that have been imprinted by TGF-beta during activation and expansion, which potentially leads to increased secretion of pro-inflammatory cytokines and enhanced antitumor immune response (NCI Drug Dictionary). | |||
| Temozolomide | Temodar | Methazolastone|TMZ | Chemotherapy - Alkylating 18 | Temodar (temozolomide) is a dacarbazine analog and cytotoxic alkylating agent (NCI Drug Dictionary). |
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| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|
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| Clinical Trial | Phase | Therapies | Title | Recruitment Status | Covered Countries | Other Countries |
|---|---|---|---|---|---|---|
| NCT05588453 | Phase Ib/II | Temozolomide + TGF-beta-imprinted NK cells | Natural Killer Cell Therapy (UD TGFbetai NK Cells) and Temozolomide for the Treatment of Stage IV Melanoma Metastatic to the Brain | Recruiting | USA | 0 |
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