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Therapy Detail
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| Therapy Name | CD19-22.BB.z CAR T cells |
| Synonyms | |
| Therapy Description |
CD19-22.BB.z CAR T cells are T-lymphocytes engineered to express a chimeric antigen receptor (CAR) that targets CD19 and CD22, which potentially induce killing of tumor cells expressing CD19 and/or CD22 and decrease tumor growth (PMID: 34312556, PMID: 29155426). |
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| Drug Name | Trade Name | Synonyms | Drug Classes | Drug Description |
|---|---|---|---|---|
| CD19-22.BB.z CAR T cells | CD19 Immune Cell Therapy 65 CD22 Immune Cell Therapy 15 | CD19-22.BB.z CAR T cells are T-lymphocytes engineered to express a chimeric antigen receptor (CAR) that targets CD19 and CD22, which potentially induce killing of tumor cells expressing CD19 and/or CD22 and decrease tumor growth (PMID: 34312556, PMID: 29155426). |
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| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|
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| Clinical Trial | Phase | Therapies | Title | Recruitment Status | Covered Countries | Other Countries |
|---|---|---|---|---|---|---|
| NCT05507827 | Phase I | CD19-22.BB.z CAR T cells | Myeloablative Conditioning Orca-T & Allogeneic Donor-Derived CD19/CD22-CAR TCells in B-Cell ALL | Recruiting | USA | 0 |
| NCT05098613 | Phase I | CD19-22.BB.z CAR T cells | Preliminary Safety and Tolerability of CD19x22 CAR T Cells in Adolescent and Adult R/R B-NHL Patients | Recruiting | USA | 0 |
| NCT03233854 | Phase I | Cyclophosphamide + Fludarabine CD19-22.BB.z CAR T cells NKTR-255 | CD19/CD22 Chimeric Antigen Receptor (CAR) T Cells With or Without NKTR-255 in Adults With Recurrent or Refractory B Cell Malignancies | Active, not recruiting | USA | 0 |
| NCT06559189 | Phase I | CD19-22.BB.z CAR T cells | CD19x22 Chimeric Antigen Receptor T-cell Therapy (CAR T) in Pediatric B-ALL | Recruiting | USA | 0 |
| NCT03241940 | Phase I | Cyclophosphamide + Fludarabine CD19-22.BB.z CAR T cells | Phase I Dose Escalation Study of CD19/CD22 Chimeric Antigen Receptor (CAR) T Cells in Children and Young Adults With Recurrent or Refractory B Cell Malignancies | Recruiting | USA | 0 |
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