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Therapy Name CTX-8371
Synonyms
Therapy Description

CTX-8371 is a tetravalent bispecific antibody that targets CD274 (PD-L1) and PDCD1 (PD-1), potentially resulting in enhanced antitumor immune response and inhibition of tumor growth (PMID: 38379869).

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Drug Name Trade Name Synonyms Drug Classes Drug Description
CTX-8371 CTX 8371|CTX8371 Immune Checkpoint Inhibitor 149 PD-L1/PD-1 antibody 122 CTX-8371 is a tetravalent bispecific antibody that targets CD274 (PD-L1) and PDCD1 (PD-1), potentially resulting in enhanced antitumor immune response and inhibition of tumor growth (PMID: 38379869).

Filtering

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  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
CD274 positive colon cancer sensitive CTX-8371 Preclinical Actionable In a preclinical study, CTX-8371 treatment resulted in greater tumor growth inhibition than either Keytruda (pembrolizumab) or Tecentriq (atezolizumab) in a syngeneic mouse model of colon cancer expressing CD274 (PD-L1), with tumor regression in 62.5% (5/8) of the treated mouse models (PMID: 38379869). 38379869
CD274 positive melanoma sensitive CTX-8371 Preclinical Actionable In a preclinical study, CTX-8371 treatment resulted in fewer lung metastases than either Keytruda (pembrolizumab) or Tecentriq (atezolizumab) monotherapy in a syngeneic mouse model of melanoma expressing CD274 (PD-L1) (PMID: 38379869). 38379869

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

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Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries
NCT06150664 Phase I CTX-8371 A Phase 1 of CTX-8371 in Patients With Advanced Malignancies Recruiting USA 0


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