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Therapy Name iC9-CAR.B7-H3 T-cells
Synonyms
Therapy Description

iC9-CAR.B7-H3 T-cells are T lymphocytes engineered to express a chimeric antigen receptor (CAR) targeting B7-H3 (CD276) and an inducible caspase 9, which potentially induce killing of B7-H3 (CD276)-expressing tumor cells (Journal for ImmunoTherapy of Cancer 2023;11).

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Drug Name Trade Name Synonyms Drug Classes Drug Description
iC9-CAR.B7-H3 T-cells iC9-CAR.B7-H3 T cells iC9-CAR.B7-H3 T-cells are T lymphocytes engineered to express a chimeric antigen receptor (CAR) targeting B7-H3 (CD276) and an inducible caspase 9, which potentially induce killing of B7-H3 (CD276)-expressing tumor cells (Journal for ImmunoTherapy of Cancer 2023;11).

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries
NCT06305299 Phase I Cyclophosphamide + Fludarabine iC9-CAR.B7-H3 T-cells Autologous CAR-T Cells Targeting B7H3 in Ovarian Cancer iC9-CAR.B7-H3 T Cells Recruiting USA 0
NCT06347068 Phase I iC9-CAR.B7-H3 T-cells Cyclophosphamide + Fludarabine Study of Autologous CAR-T Cells Targeting B7-H3 in TNBC iC9-CAR.B7-H3 T Cells Recruiting USA 0
NCT06158139 Phase I iC9-CAR.B7-H3 T-cells Autologous CAR-T Cells Targeting B7-H3 in PDAC Recruiting USA 0


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