Therapy Detail
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| Therapy Name | SP-002 + Vismodegib |
| Synonyms | |
| Therapy Description | |
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| Drug Name | Trade Name | Synonyms | Drug Classes | Drug Description |
|---|---|---|---|---|
| SP-002 | SP002|SP 002 | USP1 inhibitor 7 | SP-002 inhibits USP1, which potentially decreases growth of tumors with homologous repair deficiency (Cancer Res (2023) 83 (7_Supplement): 6201). | |
| Vismodegib | Erivedge | GDC-0449 | SMO Inhibitor 16 | Erivedge (vismodegib) binds to and inhibits Smoothened (SMO), resulting in inhibition of downstream signaling and decreased tumor growth (PMID: 24259609, PMID: 19716296). Erivedge (vismodegib) is FDA approved for use in patients with basal cell carcinoma (FDA.gov). |
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| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|
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- Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
- Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")
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- Click on any column header arrows to sort by that column
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| Clinical Trial | Phase | Therapies | Title | Recruitment Status | Covered Countries | Other Countries |
|---|---|---|---|---|---|---|
| NCT06344052 | Phase II | Vismodegib SP-002 + Vismodegib | To Assess the Safety and Efficacy of SP-002 With Vismodegib for the Treatment of Locally Advanced Basal Cell Carcinoma | Recruiting | USA | 0 |
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