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Therapy Name KIND T cells
Synonyms
Therapy Description

KIND T cells are HLA-A2+ CD8+ T-lymphocytes engineered to express a T-cell receptor (TCR) targeting the histone H3.3 K27M (K28M) mutation, which potentially induce killing of tumor cells expressing HLA-A2+ and H3.3K27M (PMID: 29203539).

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Drug Name Trade Name Synonyms Drug Classes Drug Description
KIND T cells KIND T cells are HLA-A2+ CD8+ T-lymphocytes engineered to express a T-cell receptor (TCR) targeting the histone H3.3 K27M (K28M) mutation, which potentially induce killing of tumor cells expressing HLA-A2+ and H3.3K27M (PMID: 29203539).

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries
NCT05478837 Phase I Cyclophosphamide + Fludarabine KIND T cells Genetically Modified Cells (KIND T Cells) for the Treatment of HLA-A*0201-Positive Patients With H3.3K27M-Mutated Glioma (PNOC018) Recruiting USA 0


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