Therapy Detail
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| Therapy Name | Camizestrant + Saruparib |
| Synonyms | |
| Therapy Description | |
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| Drug Name | Trade Name | Synonyms | Drug Classes | Drug Description |
|---|---|---|---|---|
| Camizestrant | Etcamah | AZD-9833|AZD9 833|AZD9833|AZ-14066724 | Hormone - Anti-estrogens 31 | Etcamah (camizestrant) is a selective estrogen receptor degrader, which leads to growth inhibition of ER-positive tumors (Journal of Clinical Oncology 38, no. 15_suppl (May 20, 2020) 1024-1024). Etcamah (camizestrant) in combination with a CDK4/6 inhibitor is FDA-approved for use in patients with hormone receptor-positive, ERBB2 (HER2)-negative advanced or metastatic breast cancer harboring ESR1 (ERalpha) mutations (FDA.gov). |
| Saruparib | AZD 5305|AZD-5305|AZD5305 | PARP-1 Inhibitor 13 | Saruparib (AZD5305) inhibits PARP1, potentially leading to tumor growth inhibition (PMID: 35929986). |
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| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|
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| Clinical Trial | Phase | Therapies | Title | Recruitment Status | Covered Countries | Other Countries |
|---|---|---|---|---|---|---|
| NCT06380751 | Phase III | Ribociclib Anastrozole Letrozole Anastrozole + Saruparib Fulvestrant + Saruparib Letrozole + Saruparib Exemestane Abemaciclib Exemestane + Saruparib Fulvestrant Camizestrant + Saruparib Camizestrant + Ribociclib Camizestrant + Palbociclib Abemaciclib + Camizestrant Palbociclib | Saruparib (AZD5305) Plus Camizestrant or Plus Endocrine Therapy, Compared With CDK4/6 Inhibitor Plus Endocrine Therapy or Plus Camizestrant in HR-Positive, HER2-Negative (IHC 0, 1+, 2+/ ISH Non-amplified), BRCA1, BRCA2, or PALB2m Advanced Breast Cancer (EvoPAR-BR01) | Recruiting | USA | TUR | POL | ITA | ISR | HUN | GBR | FRA | ESP | DEU | CZE | CAN | BRA | BGR | AUT | AUS | ARG | 12 |
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