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Therapy Name | SENTI-202 |
Synonyms | |
Therapy Description |
SENTI-202 comprises allogeneic NK-cells engineered to express a chimeric antigen receptor (CAR) targeting CD33 and FLT3 along with an inhibitory CAR (iCAR) targeting EMCN on healthy hematopoietic stem cells and progenitor cells, which potentially induces a cytotoxic immune response against tumor cells expressing CD33 and/or FLT3 (Cancer Res (2023) 83 (7_Supplement): 3195). |