Therapy Detail

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Therapy Name Budigalimab + Gemcitabine + Nab-paclitaxel + TTX-030
Synonyms
Therapy Description

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Drug Name Trade Name Synonyms Drug Classes Drug Description
Budigalimab ABBV181|ABBV 181|ABBV-181 Immune Checkpoint Inhibitor 149 PD-L1/PD-1 antibody 121 Budigalimab is a monoclonal antibody that targets PD-1 (PDCD1) and inhibits binding of the PD-L1 (CD274) ligand, potentially resulting in enhanced anti-tumor immune response (PMID: 32770720).
Gemcitabine Gemzar Difluorodeoxycytidine Hydrochlorothiazide|LY-188011 Chemotherapy - Antimetabolite 14 Gemzar (gemcitabine) is converted in cells to difluorodeoxycytidine di- and triphosphate (dFdCDP, dFdCTP), which act to inhibit ribonucleoside reductase and as a deoxynucleotide analog respectively, resulting in DNA strand termination and apoptosis (NCI Drug Dictionary).
Nab-paclitaxel Abraxane ABI-007|Paclitaxel Protein-bound Chemotherapy - Taxane 3 Abraxane (nab-paclitaxel) is an albumin-stablized version of paclitaxel, which binds microtubules and prevents depolymerization, resulting in decreased cell motility and division (NCI Drug Dictionary).
TTX-030 TTX030|TTX 030 Adenosine Targeting 23 CD39 Antibody 5 TTX-030 is a monoclonal antibody that binds to and inhibits soluble and membrane-bound ENTPD1 (CD39), resulting in decreased ATP hydrolysis, which potentially leads to activation of T-lymphocytes and anti-tumor immune response (AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 5012).

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References

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Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries
NCT06119217 Phase II Gemcitabine + Nab-paclitaxel + TTX-030 Gemcitabine + Nab-paclitaxel Budigalimab + Gemcitabine + Nab-paclitaxel + TTX-030 Phase 2 Study of TTX-030 and Chemotherapy With or Without Budigalimab for 1L mPDAC Patients Recruiting USA | ITA | FRA | ESP | AUS 2


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