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Therapy Name TranspoCART19
Synonyms
Therapy Description

TranspoCART19 is a transposon-based chimeric antigen receptor (CAR) T-cell therapy targeting CD19 that contains TNFRSF9 (4-1BB) and CD3zeta endodomains fused to a truncated human epidermal growth factor receptor (hEGFRt) as a safety switch, which potentially enhances antitumor immune response and inhibits tumor growth (PMID: 40034423).

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Drug Name Trade Name Synonyms Drug Classes Drug Description
TranspoCART19 Transpo-CART19|Transpo CART19 CD19 Immune Cell Therapy 72 TranspoCART19 is a transposon-based chimeric antigen receptor (CAR) T-cell therapy targeting CD19 that contains TNFRSF9 (4-1BB) and CD3zeta endodomains fused to a truncated human epidermal growth factor receptor (hEGFRt) as a safety switch, which potentially enhances antitumor immune response and inhibits tumor growth (PMID: 40034423).

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries
NCT06378190 Phase Ib/II TranspoCART19 Treatment of Relapsed or Refractory B-cell Lymphoma With Chimeric Antigen Receptor (CAR) T-cell Therapy Produced by a New Technology (TranspoCART19) Recruiting ESP 0


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