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Therapy Name | TranspoCART19 |
Synonyms | |
Therapy Description |
TranspoCART19 is a transposon-based chimeric antigen receptor (CAR) T-cell therapy targeting CD19 that contains TNFRSF9 (4-1BB) and CD3zeta endodomains fused to a truncated human epidermal growth factor receptor (hEGFRt) as a safety switch, which potentially enhances antitumor immune response and inhibits tumor growth (PMID: 40034423). |