Therapy Detail

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Therapy Name	Flonoltinib maleate
Synonyms
Therapy Description	Flonoltinib maleate inhibits JAK2 and FLT3, which potentially decreases downstream signaling and tumor growth (PMID: 35256594).

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Drug Name	Trade Name	Synonyms	Drug Classes	Drug Description
Flonoltinib maleate			FLT3 Inhibitor 69 JAK2 Inhibitor 19	Flonoltinib maleate inhibits JAK2 and FLT3, which potentially decreases downstream signaling and tumor growth (PMID: 35256594).

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Molecular Profile	Indication/Tumor Type	Response Type	Therapy Name	Approval Status	Evidence Type	Efficacy Evidence	References
FLT3 exon 14 ins	acute myeloid leukemia	sensitive	Flonoltinib maleate	Preclinical - Cell culture	Actionable	In a preclinical study, Flonoltinib maleate inhibited Flt3 pathway signaling and cell cycle progression and induced apoptosis in acute myeloid leukemia cells harboring a FLT3-ITD in culture (PMID: 35256594).	35256594
FLT3 exon 14 ins	hematologic cancer	sensitive	Flonoltinib maleate	Preclinical - Cell culture	Actionable	In a preclinical study, Flonoltinib maleate inhibited proliferation of a cell line expressing a FLT3-ITD in culture (PMID: 35256594).	35256594
FLT3 exon 14 ins FLT3 D835V	hematologic cancer	sensitive	Flonoltinib maleate	Preclinical - Cell culture	Actionable	In a preclinical study, Flonoltinib maleate inhibited proliferation of a cell line expressing a FLT3-ITD and FLT3 D835V in culture (PMID: 35256594).	35256594
JAK2 V617F	acute myeloid leukemia	sensitive	Flonoltinib maleate	Preclinical - Cell culture	Actionable	In a preclinical study, Flonoltinib maleate inhibited Jak/Stat signaling and cell cycle progression and induced apoptosis in an acute myeloid leukemia cell line harboring JAK2 V617F in culture (PMID: 35256594).	35256594
JAK2 V617F	myeloproliferative neoplasm	sensitive	Flonoltinib maleate	Preclinical - Cell culture	Actionable	In a preclinical study, Flonoltinib maleate inhibited Jak/Stat signaling and colony formation in myeloproliferative neoplasm patient-derived cells harboring JAK2 V617F in culture (PMID: 35256594).	35256594
JAK2 V617F	hematologic cancer	sensitive	Flonoltinib maleate	Preclinical	Actionable	In a preclinical study, Flonoltinib maleate inhibited Jak2 downstream signaling and proliferation and induced apoptosis in a cell line expressing JAK2 V617F in culture and increased survival in a mouse model (PMID: 35256594).	35256594
JAK2 V617F	myelofibrosis	sensitive	Flonoltinib maleate	Preclinical	Actionable	In a preclinical study, Flonoltinib maleate decreased splenomegaly and improved survival in a mouse model of myelofibrosis harboring JAK2 V617F (PMID: 35256594).	35256594

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