Therapy Detail
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| Therapy Name | Flonoltinib maleate |
| Synonyms | |
| Therapy Description |
Flonoltinib maleate inhibits JAK2 and FLT3, which potentially decreases downstream signaling and tumor growth (PMID: 35256594). |
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| Drug Name | Trade Name | Synonyms | Drug Classes | Drug Description |
|---|---|---|---|---|
| Flonoltinib maleate | FLT3 Inhibitor 69 JAK2 Inhibitor 19 | Flonoltinib maleate inhibits JAK2 and FLT3, which potentially decreases downstream signaling and tumor growth (PMID: 35256594). |
Filtering
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- Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
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- Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")
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| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|---|---|---|---|---|---|---|
| JAK2 V617F | myeloproliferative neoplasm | sensitive | Flonoltinib maleate | Preclinical - Cell culture | Actionable | In a preclinical study, Flonoltinib maleate inhibited Jak/Stat signaling and colony formation in myeloproliferative neoplasm patient-derived cells harboring JAK2 V617F in culture (PMID: 35256594). | 35256594 |
| FLT3 exon 14 ins | hematologic cancer | sensitive | Flonoltinib maleate | Preclinical - Cell culture | Actionable | In a preclinical study, Flonoltinib maleate inhibited proliferation of a cell line expressing a FLT3-ITD in culture (PMID: 35256594). | 35256594 |
| FLT3 exon 14 ins | acute myeloid leukemia | sensitive | Flonoltinib maleate | Preclinical - Cell culture | Actionable | In a preclinical study, Flonoltinib maleate inhibited Flt3 pathway signaling and cell cycle progression and induced apoptosis in acute myeloid leukemia cells harboring a FLT3-ITD in culture (PMID: 35256594). | 35256594 |
| FLT3 exon 14 ins FLT3 D835V | hematologic cancer | sensitive | Flonoltinib maleate | Preclinical - Cell culture | Actionable | In a preclinical study, Flonoltinib maleate inhibited proliferation of a cell line expressing a FLT3-ITD and FLT3 D835V in culture (PMID: 35256594). | 35256594 |
| JAK2 V617F | acute myeloid leukemia | sensitive | Flonoltinib maleate | Preclinical - Cell culture | Actionable | In a preclinical study, Flonoltinib maleate inhibited Jak/Stat signaling and cell cycle progression and induced apoptosis in an acute myeloid leukemia cell line harboring JAK2 V617F in culture (PMID: 35256594). | 35256594 |
| JAK2 V617F | myelofibrosis | sensitive | Flonoltinib maleate | Preclinical | Actionable | In a preclinical study, Flonoltinib maleate decreased splenomegaly and improved survival in a mouse model of myelofibrosis harboring JAK2 V617F (PMID: 35256594). | 35256594 |
| JAK2 V617F | hematologic cancer | sensitive | Flonoltinib maleate | Preclinical | Actionable | In a preclinical study, Flonoltinib maleate inhibited Jak2 downstream signaling and proliferation and induced apoptosis in a cell line expressing JAK2 V617F in culture and increased survival in a mouse model (PMID: 35256594). | 35256594 |
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| Clinical Trial | Phase | Therapies | Title | Recruitment Status | Covered Countries | Other Countries |
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