Therapy Detail
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| Therapy Name | Doxorubicin + Onfekafusp alfa |
| Synonyms | |
| Therapy Description | |
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| Drug Name | Trade Name | Synonyms | Drug Classes | Drug Description |
|---|---|---|---|---|
| Doxorubicin | Adriamycin | Adria|ADR|Doxorubicin hydrochloride|Hydroxydaunorubicin | Chemotherapy - Anthracycline 13 TOPO2 inhibitor 5 | Adriamycin (doxorubicin) is an anthracycline chemotherapeutic, in a non-liposomal formulation, which intercalates into DNA and inhibits topoisomerase II (PMID: 24367159). Doxorubicin is FDA approved for multiple cancer types (FDA.gov). |
| Onfekafusp alfa | Fibromun|L19-TNF-alpha|L19TNF | Onfekafusp alfa comprises TNFalpha linked to a single chain variable fragment targeting fibronectin extra-domain B, which may increase antitumor immune response (NCI Drug Dictionary). |
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| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|
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| Clinical Trial | Phase | Therapies | Title | Recruitment Status | Covered Countries | Other Countries |
|---|---|---|---|---|---|---|
| NCT04650984 | Phase III | Doxorubicin + Onfekafusp alfa Doxorubicin | A Study Comparing the Efficacy of L19TNF+Doxorubicin vs Doxorubicin Alone as First-line Therapy in Patients With Advanced or Metastatic Soft Tissue Sarcoma (FIBROSARC) | Recruiting | POL | ITA | FRA | ESP | DEU | 0 |
| NCT03420014 | Phase II | Doxorubicin + Onfekafusp alfa Doxorubicin | Treatment of Metastatic Soft Tissue Sarcoma (STS) Patients (FIBROSARC USA) (FIBROSARC US) | Recruiting | USA | 0 |
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