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Therapy Name | FT536 |
Synonyms | |
Therapy Description |
FT536 comprises iPSC-derived natural killer cells with deletion of CD38 and expressing an IL-15-IL15 receptor fusion and non-cleavable CD16 that have been engineered to express a chimeric antigen receptor (CAR) targeting the alpha3 domain of MICA and MICB, which potentially inhibits growth of MICA/B-expressing tumors (Cancer Res (2021) 81 (13_Supplement): 1591). |