Therapy Detail
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| Therapy Name | MRX-2843 + Venetoclax |
| Synonyms | |
| Therapy Description | |
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| Drug Name | Trade Name | Synonyms | Drug Classes | Drug Description |
|---|---|---|---|---|
| MRX-2843 | MRX2843|MRX 2843 | FLT3 Inhibitor 69 MERTK Inhibitor 13 TYRO3 Inhibitor 8 | MRX-2843 is a small molecule inhibitor of MERTK, FLT3 and TYRO3, resulting in apoptosis and anti-tumor effects (PMID: 27158668, PMID: 30501104). | |
| Venetoclax | Venclexta | ABT-199|RG7601|GDC-0199|ABT119|Venclyxto | BCL2 inhibitor 27 | Venclexta (venetoclax) is a BH3-mimetic that binds to and inhibits BCL2, resulting in increased tumor cell apoptosis (PMID: 26589495, PMID: 25048785). Venclexta (venetoclax) is FDA approved for use in patients with chronic lymphocytic leukemia (CLL) or small lymphocytic lymphoma (SLL), and in combination with chemotherapy in patients 75 years old or older with newly-diagnosed acute myeloid leukemia (FDA.gov). |
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| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|---|---|---|---|---|---|---|
| FLT3 exon 14 ins | acute myeloid leukemia | sensitive | MRX-2843 + Venetoclax | Preclinical - Patient cell culture | Actionable | In a preclinical study, the combination of MRX-2843 and Venclexta (venetoclax) induced apoptosis in acute myeloid leukemia (AML) cell lines harboring a FLT3-ITD, including cell lines resistant to Cytosar-U (cytarabine), and induced apoptosis and inhibited colony growth in primary AML cells harboring a FLT3-ITD in culture (PMID: 38968731). | 38968731 |
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| Clinical Trial | Phase | Therapies | Title | Recruitment Status | Covered Countries | Other Countries |
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