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Therapy Name ADP-A2M4CD8
Synonyms
Therapy Description

ADP-A2M4CD8 comprises autologous T-cells engineered to express a CD8alpha co-receptor and a T-cell receptor (TCR) targeting MAGE-A4, which potentially induces antitumor activity (J Clin Oncol 41, 2023 (suppl 6; abstr 517)).

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Drug Name Trade Name Synonyms Drug Classes Drug Description
ADP-A2M4CD8 Uzatresgene autoleucel|MAGE-A4 SPEAR CD8alpha T-cells|uza-cel ADP-A2M4CD8 comprises autologous T-cells engineered to express a CD8alpha co-receptor and a T-cell receptor (TCR) targeting MAGE-A4, which potentially induces antitumor activity (J Clin Oncol 41, 2023 (suppl 6; abstr 517)).

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries
NCT05601752 Phase II ADP-A2M4CD8 ADP-A2M4CD8 Monotherapy and in Combination With Nivolumab in HLA-A2+ Subjects With MAGE-A4 Positive Ovarian Cancer (SURPASS-3) Recruiting USA | GBR | FRA | ESP | CAN 0


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