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Therapy Name Decitabine and Cedazuridine
Synonyms
Therapy Description

Inqovi (decitabine and cedazuridine) is a combination of decitabine and cedazuridine, which may inhibit proliferation of tumor cells (PMID: 30926081). Inqovi (decitabine and cedazuridine) is an FDA approved chemotherapy agent (FDA.gov).

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Drug Name Trade Name Synonyms Drug Classes Drug Description
Decitabine and Cedazuridine Inqovi ASTX-727|ASTX 727|ASTX727 Chemotherapy - Antimetabolite 14 Inqovi (decitabine and cedazuridine) is a combination of decitabine and cedazuridine, which may inhibit proliferation of tumor cells (PMID: 30926081). Inqovi (decitabine and cedazuridine) is an FDA approved chemotherapy agent (FDA.gov).

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  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
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  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References

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Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries
NCT03306264 Phase III Decitabine Decitabine and Cedazuridine Study of ASTX727 vs IV Decitabine in MDS, CMML, and AML Completed USA | ITA | HUN | GBR | FRA | ESP | DEU | CZE | CAN | AUT 0
NCT03922555 Phase I Decitabine and Cedazuridine ASTX727 in Recurrent/Progressive Non-enhancing IDH Mutant Gliomas Recruiting USA 0
NCT06661915 Phase II Decitabine and Cedazuridine Decitabine and Cedazuridine + ORY-1001 A Randomized Study of ASTX727 With or Without Iadademstat in Advanced Myeloproliferative Neoplasms (MPNs) Recruiting USA 0
NCT05564390 Phase II Decitabine and Cedazuridine Fludarabine + Melphalan Epoetin alfa + Luspatercept Decitabine and Cedazuridine + Enasidenib CA-4948 + Luspatercept Decitabine and Cedazuridine + Olutasidenib Azacitidine + Gilteritinib + Venetoclax Decitabine and Cedazuridine + Venetoclax Cytarabine + Daunorubicin + Gemtuzumab ozogamicin CPX-351 Olutasidenib Decitabine and Cedazuridine + Enasidenib + Venetoclax Cytarabine + Venetoclax Cytarabine + Daunorubicin + Venetoclax CPX-351 + Venetoclax Cytarabine + Daunorubicin Cytarabine Luspatercept Azacitidine + Venetoclax Decitabine and Cedazuridine + Olutasidenib + Venetoclax MYELOMATCH: A Screening Study to Assign People With Myeloid Cancer to a Treatment Study or Standard of Care Treatment Within myeloMATCH (MyeloMATCH Screening Trial) Recruiting USA | CAN 1
NCT06577441 Phase II Decitabine and Cedazuridine + Enasidenib Decitabine and Cedazuridine Testing the Addition of an IDH2 Inhibitor, Enasidenib, to Usual Treatment (Cedazuridine-Decitabine) for Higher-Risk Myelodysplastic Syndrome (MDS) With IDH2 Mutation (A MyeloMATCH Treatment Trial) Recruiting USA 1
NCT03613532 Phase I Azacitidine + Venetoclax Busulfan + Fludarabine + Venetoclax Decitabine and Cedazuridine Venetoclax Added to Fludarabine + Busulfan Prior to Transplant and to Maintenance Therapy for AML, MDS, and MDS/MPN Active, not recruiting USA 0
NCT06297629 Phase II Decitabine and Cedazuridine A Phase I/II Trial to Assess the Efficacy and Toxicity of ASTX727 (Oral Decitabine/Cedazuridine) for the Treatment of Hematological Neoplasms After Allogeneic Stem Cell Transplantation Withdrawn USA 0
NCT05360160 Phase Ib/II Decitabine and Cedazuridine Revumenib Venetoclax A Phase I-II Study Investigating the All Oral Combination of the Menin Inhibitor SNDX-5613 With Decitabine/Cedazuridine (ASTX727) and Venetoclax in Acute Myeloid Leukemia (SAVE) Recruiting USA 0
NCT05010772 Phase I Decitabine and Cedazuridine Decitabine and Cedazuridine + Ivosidenib Decitabine and Cedazuridine + Gilteritinib Decitabine and Cedazuridine + Enasidenib Decitabine and Cedazuridine + Venetoclax Decitabine Alone or in Combination With Venetoclax, Gilteritinib, Enasidenib, or Ivosidenib as Maintenance Therapy for the Treatment of Acute Myeloid Leukemia in Remission Recruiting USA 0
NCT04872543 Phase II Decitabine and Cedazuridine A Study of ASTX727 in People With Malignant Peripheral Nerve Sheath Tumors (MPNST) Recruiting USA 0
NCT02103478 Phase Ib/II Decitabine and Cedazuridine Pharmacokinetic Guided Dose Escalation and Dose Confirmation With Oral Decitabine and Oral CDAi in Patients With MDS Completed USA | CAN 0
NCT05600894 Phase II Decitabine and Cedazuridine Decitabine and Cedazuridine + Venetoclax Venetoclax in Combination With ASTX727 for the Treatment of Chronic Myelomonocytic Leukemia and Other Myelodysplastic Syndrome/Myeloproliferative Neoplasm With Excess Blasts Active, not recruiting USA | CAN 0


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