Therapy Detail
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| Therapy Name | BGB-B2033 |
| Synonyms | |
| Therapy Description |
BGB-B2033 is a bispecific antibody targeting TNFRSF9 (4-1BB) and GPC3, which potentially induces killing of GPC3-expressing tumor cells and antitumor activity (Cancer Res (2025) 85 (8_Supplement_1): 6009). |
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| Drug Name | Trade Name | Synonyms | Drug Classes | Drug Description |
|---|---|---|---|---|
| BGB-B2033 | BGB B2033|BGBB2033 | GPC3 Antibody 7 TNFRSF9 Antibody 36 | BGB-B2033 is a bispecific antibody targeting TNFRSF9 (4-1BB) and GPC3, which potentially induces killing of GPC3-expressing tumor cells and antitumor activity (Cancer Res (2025) 85 (8_Supplement_1): 6009). |
Filtering
- Case insensitive filtering will display rows if any text in any cell matches the filter term
- Use simple literal full or partial string matches
- Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
- Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
- Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")
Sorting
- Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
- Click on any column header arrows to sort by that column
- Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.
| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|
Filtering
- Case insensitive filtering will display rows if any text in any cell matches the filter term
- Use simple literal full or partial string matches
- Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
- Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
- Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")
Sorting
- Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
- Click on any column header arrows to sort by that column
- Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.
| Clinical Trial | Phase | Therapies | Title | Recruitment Status | Covered Countries | Other Countries |
|---|---|---|---|---|---|---|
| NCT06427941 | Phase I | BGB-B2033 BGB-B2033 + Tislelizumab | A Phase 1 Study of BGB-B2033, Alone or in Combination With Tislelizumab, in Participants With Advanced or Metastatic Solid Tumors | Recruiting | USA | NZL | 2 |
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