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Therapy Name	BH-30643
Synonyms
Therapy Description	BH-30643 is a reversible, mutant-selective inhibitor of EGFR and ERBB2 (HER2) with activity against EGFR exon 20 insertions, EGFR exon 19 deletions, EGFR T790M, EGFR L858R, and EGFR C797S, which potentially inhibits tumor cell proliferation (Cancer Res (2025) 85 (8_Supplement_1): 5608).

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Drug Name	Trade Name	Synonyms	Drug Classes	Drug Description
BH-30643		BH 30643\|BH30643	EGFR Exon 20 Insertion Inhibitor 15 EGFR Inhibitor 4th gen 19 HER2 Inhibitor 44	BH-30643 is a reversible, mutant-selective inhibitor of EGFR and ERBB2 (HER2) with activity against EGFR exon 20 insertions, EGFR exon 19 deletions, EGFR T790M, EGFR L858R, and EGFR C797S, which potentially inhibits tumor cell proliferation (Cancer Res (2025) 85 (8_Supplement_1): 5608).

Filtering

Case insensitive filtering will display rows if any text in any cell matches the filter term
Use simple literal full or partial string matches
Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

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Molecular Profile	Indication/Tumor Type	Response Type	Therapy Name	Approval Status	Evidence Type	Efficacy Evidence	References

Filtering

Case insensitive filtering will display rows if any text in any cell matches the filter term
Use simple literal full or partial string matches
Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
Click on any column header arrows to sort by that column
Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Clinical Trial	Phase	Therapies	Title	Recruitment Status	Covered Countries	Other Countries
NCT06706076	Phase Ib/II	BH-30643	A Study of BH-30643 in Subjects with Locally Advanced or Metastatic NSCLC Harboring EGFR And/or HER2 Mutations (SOLARA)	Recruiting	USA \| CAN \| AUS	5

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