Therapy Detail
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| Therapy Name | PRAME-TCR-NK cells |
| Synonyms | |
| Therapy Description |
PRAME-TCR-NK cells are allogeneic natural killer cells engineered to express a T-cell receptor (TCR) targeting PRAME, which may induce anti-tumor activity against tumor cells expressing PRAME (Journal for ImmunoTherapy of Cancer 2024;12). |
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| Drug Name | Trade Name | Synonyms | Drug Classes | Drug Description |
|---|---|---|---|---|
| PRAME-TCR-NK cells | PRAME TCR/IL-15 NK cells|PRAME-TCR-NKs|SY-307 | PRAME-TCR-NK cells are allogeneic natural killer cells engineered to express a T-cell receptor (TCR) targeting PRAME, which may induce anti-tumor activity against tumor cells expressing PRAME (Journal for ImmunoTherapy of Cancer 2024;12). |
Filtering
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- Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
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- Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")
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| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|
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- Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")
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- Click on any column header arrows to sort by that column
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| Clinical Trial | Phase | Therapies | Title | Recruitment Status | Covered Countries | Other Countries |
|---|---|---|---|---|---|---|
| NCT06660420 | Phase I | PRAME-TCR-NK cells Cyclophosphamide + Fludarabine | Phase 1 Dose Escalation and Expansion Study of PRAME T Cell Receptor (TCR) Engineered NK Cells in Participants With Recurrent and/or Refractory Melanoma (PRAMETIME-Mel) | Recruiting | USA | 0 |
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