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Therapy Name PRAME-TCR-NK cells
Synonyms
Therapy Description

PRAME-TCR-NK cells are allogeneic natural killer cells engineered to express a T-cell receptor (TCR) targeting PRAME, which may induce anti-tumor activity against tumor cells expressing PRAME (Journal for ImmunoTherapy of Cancer 2024;12).

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Drug Name Trade Name Synonyms Drug Classes Drug Description
PRAME-TCR-NK cells PRAME TCR/IL-15 NK cells|PRAME-TCR-NKs|SY-307 PRAME-TCR-NK cells are allogeneic natural killer cells engineered to express a T-cell receptor (TCR) targeting PRAME, which may induce anti-tumor activity against tumor cells expressing PRAME (Journal for ImmunoTherapy of Cancer 2024;12).

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries
NCT06660420 Phase I PRAME-TCR-NK cells Cyclophosphamide + Fludarabine Phase 1 Dose Escalation and Expansion Study of PRAME T Cell Receptor (TCR) Engineered NK Cells in Participants With Recurrent and/or Refractory Melanoma (PRAMETIME-Mel) Not yet recruiting USA 0


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