Therapy Detail
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| Therapy Name | Belantamab mafodotin-blmf + Dexamethasone + Selinexor |
| Synonyms | |
| Therapy Description | |
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| Drug Name | Trade Name | Synonyms | Drug Classes | Drug Description |
|---|---|---|---|---|
| Belantamab mafodotin-blmf | Blenrep | anti-BCMA ADC GSK2857916|J6M0-mcMMAF|GSK2857916 | TNFRSF17 Antibody 22 | Blenrep (belantamab mafodotin-blmf) is an antibody-drug conjugate comprising an antibody targeting BCMA linked to monomethyl auristatin F, which delivers the anti-microtubule agent to BCMA-expressing tumor cells, potentially resulting in increased tumor cell death and decreased tumor growth (PMID: 30442502, PMID: 24569262). Blenrep (belantamab mafodotin-blmf) in combination with Velcade (bortezomib), and Dexamethasone is FDA-approved for adult patients with relapsed or refractory multiple myeloma who have received at least two prior lines of therapy (FDA.gov). |
| Dexamethasone | Adexone | Desametasone | ||
| Selinexor | Xpovio | KPT-330 | XPO1 Inhibitor 4 | Xpovio (selinexor) inhibits CRM1 (XPO1), preventing CRM1-mediated nuclear export of tumor suppressor proteins and potentially restoring normal tumor suppressor function (PMID: 30976603, PMID: 31793336). Xpovio (selinexor) is FDA approved for use in patients with diffuse large B cell lymphoma after two or more prior therapies, in combination with Adexone (dexamethasone) in patients with relapsed or refractory multiple myeloma after at least four prior therapies, and in combination with Velcade (bortezomib) and Adexone (dexamethasone) in patients with multiple myeloma after at least one prior therapy (FDA.gov). |
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| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|
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| Clinical Trial | Phase | Therapies | Title | Recruitment Status | Covered Countries | Other Countries |
|---|---|---|---|---|---|---|
| NCT02343042 | Phase Ib/II | Dexamethasone + Ixazomib + Selinexor Daratumumab + Dexamethasone + Selinexor Dexamethasone + Pomalidomide + Selinexor Dexamethasone + Lenalidomide + Selinexor CC-92480 + Dexamethasone + Selinexor Carfilzomib + Dexamethasone + Selinexor Daratumumab + Dexamethasone + Pomalidomide + Selinexor Belantamab mafodotin-blmf + Dexamethasone + Selinexor Bortezomib + Dexamethasone + Selinexor Dexamethasone + Elotuzumab + Pomalidomide + Selinexor Bortezomib + Dexamethasone + Pomalidomide + Selinexor | Selinexor and Backbone Treatments of Multiple Myeloma Patients (STOMP) | Recruiting | USA | CAN | 0 |
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