Therapy Detail
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| Therapy Name | Bevacizumab + PRO1184 |
| Synonyms | |
| Therapy Description | |
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| Drug Name | Trade Name | Synonyms | Drug Classes | Drug Description |
|---|---|---|---|---|
| Bevacizumab | Avastin | VEGF Antibody 12 VEGFR Inhibitor (Pan) 36 | Avastin (bevacizumab) is a monoclonal antibody that binds VEGF and inhibits binding to VEGFR, potentially resulting in decreased tumor growth (PMID: 15136787). Avastin (bevacizumab) is FDA approved for use in colorectal cancer, non-small cell lung cancer, glioblastoma, renal cell carcinoma, cervical carcinoma, and ovarian cancer, and in combination with carboplatin and paclitaxel in epithelial ovarian, fallopian tube, or primary peritoneal cancer (FDA.gov). | |
| PRO1184 | PRO-1184|PRO 1184|Rinatabart Sesutecan|Rina-S|GEN1184 | FOLR1-targeted Therapy 24 | PRO1184 is an antibody-drug conjugate (ADC) comprising a monoclonal antibody targeting FOLR1 linked to exatecan, which potentially inhibits growth of FOLR1-expressing tumors (Cancer Res 2022;82(12_Suppl):Abstract nr 1085). |
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| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|
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- Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
- Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")
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| Clinical Trial | Phase | Therapies | Title | Recruitment Status | Covered Countries | Other Countries |
|---|---|---|---|---|---|---|
| NCT05579366 | Phase Ib/II | Carboplatin + PRO1184 PRO1184 Bevacizumab + PRO1184 Pembrolizumab + PRO1184 | Rinatabart Sesutecan (Rina-S) for Advanced Solid Tumors (GCT1184-01/ PRO1184-001) (PRO1184-001) | Recruiting | USA | 1 |
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