Therapy Detail
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| Therapy Name | MDG1015 |
| Synonyms | |
| Therapy Description |
MDG1015 is a T-cell receptor (TCR) therapy consisting of autologous T-lymphocytes engineered to express a TCR targeting NY-ESO-1 (CTAG1B),/LAGE-1a and a PD1-41BB costimulatory switch protein, which potentially induces an antitumor immune response against tumor cells expressing NY-ESO-1 (CTAG1B) or LAGE-1a (Ann Oncol 34 (2023): S1158, NCI Thesaurus). |
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| Drug Name | Trade Name | Synonyms | Drug Classes | Drug Description |
|---|---|---|---|---|
| MDG1015 | MDG 1015|MDG-1015 | MDG1015 is a T-cell receptor (TCR) therapy consisting of autologous T-lymphocytes engineered to express a TCR targeting NY-ESO-1 (CTAG1B),/LAGE-1a and a PD1-41BB costimulatory switch protein, which potentially induces an antitumor immune response against tumor cells expressing NY-ESO-1 (CTAG1B) or LAGE-1a (Ann Oncol 34 (2023): S1158, NCI Thesaurus). |
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| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|
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- Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
- Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
- Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")
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| Clinical Trial | Phase | Therapies | Title | Recruitment Status | Covered Countries | Other Countries |
|---|---|---|---|---|---|---|
| NCT06748872 | Phase I | MDG1015 Cyclophosphamide + Fludarabine | EPITOME-1015-I: a Study to Investigate the Safety and Tolerability of MDG1015 in Patients with Epithelial Ovarian Cancer, Gastroesophageal Adenocarcinoma, Round Cell Liposarcoma And/or Synovial Sarcoma (EPITOME-1015-I) | Not yet recruiting | USA | 0 |
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