Therapy Detail
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| Therapy Name | Bevacizumab + Fluorouracil + Leucovorin + Oxaliplatin + PF-07985045 |
| Synonyms | |
| Therapy Description | |
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| Drug Name | Trade Name | Synonyms | Drug Classes | Drug Description |
|---|---|---|---|---|
| Bevacizumab | Avastin | VEGF Antibody 12 VEGFR Inhibitor (Pan) 36 | Avastin (bevacizumab) is a monoclonal antibody that binds VEGF and inhibits binding to VEGFR, potentially resulting in decreased tumor growth (PMID: 15136787). Avastin (bevacizumab) is FDA approved for use in colorectal cancer, non-small cell lung cancer, glioblastoma, renal cell carcinoma, cervical carcinoma, and ovarian cancer, and in combination with carboplatin and paclitaxel in epithelial ovarian, fallopian tube, or primary peritoneal cancer (FDA.gov). | |
| Fluorouracil | Adrucil | 5-FU|5-Fluorouracil | Chemotherapy - Antimetabolite 14 | Adrucil (fluorouracil) is an antimetabolite chemotherapeutic agent, which interferes with DNA and RNA synthesis thereby preventing cancer cell growth and is FDA approved for colorectal, breast, stomach, and pancreatic cancer (FDA.gov). |
| Leucovorin | Wellcovorin | Calcium folinate|Calcium citrovorum factor|folinic acid | Chemotherapy - Antimetabolite 14 | Wellcovorin (leucovorin) is a metabolite of folate that enhances the efficacy of fluoruracil (PMID: 32490554). |
| Oxaliplatin | Eloxatin | Diaminocyclohexane Oxalatoplatinum | Chemotherapy - Platinum 7 | Eloxatin (oxaliplatin) is comprised of a platinum complex, which causes DNA-platinum cross-links, inhibition of DNA replication and transcription, and cell toxicity, and is FDA approved for colorectal cancer (FDA.gov). |
| PF-07985045 | PF 07985045|PF07985045 | KRAS Inhibitor 21 | Limited information is currently available on PF-07985045, a putative KRAS inhibitor (Mar 2025). |
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| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|
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| Clinical Trial | Phase | Therapies | Title | Recruitment Status | Covered Countries | Other Countries |
|---|---|---|---|---|---|---|
| NCT06704724 | Phase I | Cisplatin + Paclitaxel + Pembrolizumab + PF-07985045 PF-07284892 + PF-07985045 Cisplatin + Pembrolizumab + Pemetrexed Disodium + PF-07985045 Carboplatin + Paclitaxel + Pembrolizumab + PF-07985045 Pembrolizumab + PF-07985045 Carboplatin + Pembrolizumab + Pemetrexed Disodium + PF-07985045 Bevacizumab + Fluorouracil + Leucovorin + Oxaliplatin + PF-07985045 PF-06801591 + PF-07985045 Gemcitabine + Nab-paclitaxel + PF-07985045 Cetuximab + PF-07985045 PF-07985045 | A Study to Learn About the Study Medicine PF-07985045 When Given Alone or With Other Anti-cancer Therapies in People With Advanced Solid Tumors That Have a Change in a Gene | Recruiting | USA | 1 |
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